Our latest paper "Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse" was published in Development.
Nodal signaling is crucial for left-right patterning, however some studies have suggested differences between zebrafish and mouse. In this study, single and double mutants for genes involved in Nodal signaling were generated. Imaging of mutant phenotypes as well as biochemical and activity assays revealed the regulatory logic of this system. These results show that left-right patterning mechanisms are conserved from zebrafish to mouse.